异维A酸胶丸联合百癣夏塔热片治疗中重度寻常型痤疮临床疗效观察(1)
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[摘要] 目的：探讨异维A酸胶丸联合百癣夏塔热片治疗中重度寻常型痤疮的临床效果。方法：采用随机、平行、对照的临床试验，将78例受试对象随机分为对照组和治疗组；对照组30例常规使用异维A酸胶丸口服治疗，治疗组48例在上述治疗基础上联合百癣夏塔热片治疗，两组均外用克林霉素凝胶和0.025%迪维霜。疗程为6周，结束后观察疗效。结果：治疗组总有效率为89.58%，痊愈率为62.50%；对照组总有效率为66.67%，痊愈率为40.00%，两组疗效比较差异有统计学意义(P<0.05)。结论：异维A酸胶丸联合百癣夏塔热片治疗中重度寻常型痤疮有较好的疗效，值得临床使用。
[关键词] 寻常型痤疮；异维A酸胶丸；百癣夏塔热片；中药
[中图分类号] R758.73+3 [文献标识码] A [文章编号] 1674-4721(2012)01(b)-104-03
Observation on the efficacy of isotretinoin soft capsules combined with Baixuan Xiatare tablets for the treatment of acne vulgaris in moderate and severe degree
LIN Yingping
Huizhou Hospital For Skin Disease and STDs of Guangdong Province, Huizhou 516001, China
[Abstract] Objective: To observe clinical efficacy of isotretinoin soft capsules combined with Baixuan Xiatare tablets in the treatment of acne vulgaris in moderate and severe degree. Methods: A randomized paralled controlled clinical study was pefrormed in 78 patients with acne vulgaris in moderate and severe degree who were randomly divided into control group of 30 cases and treatment group of 48 cases. The control group was treated with routine drugs isotretinoin soft capsules, treatment group received routine theraps and Baixuan Xiatare tablets, both groups were treated with clindamycin phosphate gel and 0.025% all-trans retinoic acids cream. Measured and compared with two groups after 6 weeks. Results：There was significant difference(P<0.05) between two groups in total effective rate (89.58% in treatment group and 66.67% in control group) and total cure rate (62.50% in treatment group and 40.00% in control group). Conclusion: Isotretinoin soft capsules combined with Baixuan Xiatare tablets in treating acne vulgaris in Moderate and severe Degree has reliable effect and it is worthwhile to be recommended for clinical use.
[Key words] Acne vulgaris; Isotretinoin; Baixuan Xiatare tablets; Chinese medicine
寻常型痤疮(acne vulgaris，AV)是青春期常见的一种毛囊与皮脂腺的慢性炎症性皮肤病，好发于面部、胸部和背部。对本病的治疗方法虽然较多，但其效果并不令人满意，尤其是中重度寻常型痤疮皮损多为脓疱、结节、囊肿，故在临床上治疗起来也比较困难，对患者在社交、心理、情绪等方面的影响较大。本院在应用异维A酸胶丸等西药治疗中重度寻常型痤疮的基础上，联合使用了百癣夏塔热片，经临床观察，笔者认为中西医结合治疗中重度寻常型痤疮优于单纯西药治疗。现将结果总结如下：
1 资料与方法
1.1 一般资料
选择2009年10月～2010年8月期间在本院门诊部诊断为寻常型痤疮患者，所有病例均具有典型的中重度寻常型痤疮[1]的临床表现 ......
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